Please use this identifier to cite or link to this item: http://dspace.up.edu.ps/xmlui/handle/123456789/154
Title: The Effect of Atorvastatin on Liver Function among Patients with Coronary Heart Disease in Gaza Strip
Authors: Taleb, Mahmmoud H.
Almasri, Ihab M.
Siam, Naima I.
Najim, Ahmed A.
Ahmed, Adham I.
Keywords: Statins
Atorvastatin
Coronary Heart Disease
Liver Transaminases
Issue Date: 8-May-2014
Publisher: Pharmacology & Pharmacy
Citation: Taleb, Mahmmoud H., et al. "The effect of atorvastatin on liver function among patients with coronary heart disease in Gaza Strip." Pharmacology & Pharmacy 5.08 (2014): 781.
Abstract: Statins, which are inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are considered as one of the most important drugs and the drug of choice for reducing an abnormal cholesterol level. Statins are normally used to decrease the risk of coronary heart disease (CHD), but they tend to be associated with liver adverse effects. The objective of this prospective study was to investigate the effect of atorvastatin therapy on the liver function in patients with CHD. Study comprised of 66 newly diagnosed CHD patients who were selected from UNRWA clinics in the Gaza Strip. The patients were clinically examined and treated with atorvastatin (10 - 40 mg/day). A questionnaire was used to collect the data concerning patient’s characteristics. Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), liver enzymes tests such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and total and direct blood bilirubin were measured before starting treatment and after 3 and 6 months of treatment. The results showed a significant increase in the mean values of ALT, AST, total bilirubin and direct bilirubin levels after 3 months then decreased after the next 3 months, but they were higher than the baseline with insignificant association.
Description: The Effect of Atorvastatin on Liver Function among Patients with Coronary Heart Disease in Gaza Strip Mahmmoud H. Taleb1*, Ihab M. Almasri2, Naima I. Siam3, Ahmed A. Najim4, Adham I. Ahmed4 1Department of Pharmacology, Al-Azhar University, Gaza, Palestine 2Department of Pharmaceutical Chemistry, Al-Azhar University, Gaza, Palestine 3Faculty of Pharmacy, Al-Azhar University, Gaza, Palestine 4Faculty of Intermediate Studies, University of Palestine, Gaza, Palestine Email: *mahtaleb@hotmail.com Received 16 April 2014; revised 2 June 2014; accepted 27 June 2014 Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
URI: http://dx.doi.org/10.4236/pp.2014.58088
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